Biogune and its partners find possible way to fight liver and colon cancers

Tuesday, July 15th, 2014


A study conducted at the Basque bioscience research centre, CIC bioGUNE, the University of Liverpool and the Keck School of Medicine of the University of the Southern California, USC-UCLA (USA), has deciphered the mechanism by which two proteins, on joining up, favour the reproduction of tumour cells in cancers of the liver and the colon.

This discovery opens the door for research into pharmaceutical drugs that act on the union of these proteins, and which could thus inhibit the growth of the cancer cells.

Thanks to this discovery, it is possible to know which part of their respective structures can be blocked in order to prevent the proteins linking with each other. This is very important because when both link up, the production of a molecule called SAMe, which takes part in the uncontrolled growth of tumour cells, increases significantly.

The role of SAMe in the development of tumours has been known for some time, but this molecule has other important functions inside the cell which cannot be altered, and no way of combating this role that does not affect these tasks has been discovered to date.

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